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Opioid antagonists, for example naloxone, are precise antidotes to respiratory despair resulting from opioid overdose. For clinically important respiratory or circulatory melancholy secondary to opioid overdose, administer an opioid antagonist. Because the length of opioid reversal is anticipated to be under the duration of motion of oxycodone in oxycodone HCl tablets, meticulously observe the affected individual until spontaneous respiration is reliably reestablished.

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ROXICODONE (oxycodone HCl) tablets are indicated for that management of discomfort severe enough to involve an opioid analgesic and for which alternate solutions are inadequate.

Hypotension Tell clients that oxycodone click here HCl may well cause orthostatic hypotension and syncope. Instruct patients how to recognize symptoms of minimal blood pressure level and the way to reduce the chance of critical effects must hypotension take place (e.

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Bodily dependence is actually a state that develops on here account of a physiological adaptation in reaction to repeated drug use, manifested by withdrawal signs and indications just after abrupt discontinuation or a significant dose reduction of the drug. Withdrawal could possibly get more info be precipitated throughout the administration of medication with opioid antagonist activity (e.

Quickly stopping this medication might trigger withdrawal, particularly when you have made use of it for years or in large doses. To prevent withdrawal, your health practitioner may possibly reduce your dose gradually.

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Tend not to abruptly discontinue ROXICODONE in a very patient physically depending on opioids. When discontinuing ROXICODONE in the physically dependent patient, step by step taper the dosage.

Drug interactions may well adjust how your medicines work or enhance your hazard for severe Negative effects. This doc will not contain all doable drug interactions.

Inform your doctor if you really feel that the soreness just isn't managed or If the ache increases, results in being worse, or When you have new agony or a heightened sensitivity to pain through your remedy with oxycodone. Do not just take here much more of it or consider it much more frequently than prescribed by your physician.

Neonatal opioid withdrawal syndrome (NOWS) may well manifest adhering to prolonged usage of opioids in the course of pregnancy. Observe newborns for indications of NOWS and regulate accordingly; NOWS can be existence threatening Otherwise regarded and treated in neonates.